Temporary interruption of baricitinib: characterization of interruptions and effect on clinical outcomes in patients with rheumatoid arthritis.

In clinical practice, temporary interruption of rheumatoid arthritis (RA) therapy is common for various reasons including side effects, non-compliance, or necessity for surgery. To characterize temporary interruptions of baricitinib and placebo-matched tablets in phase 3 studies of patients with moderate-to-severe rheumatoid arthritis (RA) and describe their impact on efficacy and safety.

During 4 baricitinib phase 3 studies, investigators documented timing, reason, and duration of investigator-initiated temporary interruptions of study drug. In 2 studies, patients recorded RA symptoms in daily diaries for 12 weeks.

Post hoc analyses investigated changes in symptom scores during interruptions and resumption of treatment. Interruptions were evaluated for reoccurrence of adverse events or laboratory abnormalities after retreatment.

Across the placebo-controlled studies, interruptions occurred in larger proportions of baricitinib- (2 mg, 18%; 4 mg, 18%) vs placebo-treated (9%) patients in only one study (bDMARD-inadequate responder patients, RA-BEACON). In the active comparator-controlled studies, the lowest rates of interruption were in the baricitinib monotherapy arm (9%) of RA-BEGIN (vs methotrexate monotherapy or combination therapy), and proportions were similar for baricitinib (10%) and adalimumab (9%) in RA-BEAM.

Adverse events were the most common reason for interruption, but their reoccurrence after drug restart was infrequent. Most interruptions lasted ≤ 2 weeks. Daily diaries indicated modest symptom increases during interruption with return to pre-interruption levels or better after resumption. Interruptions had no impact on long-term efficacy outcomes.

HSP70 ELISA Kit

SKT-105-480 5 plates of 96 wells
EUR 2260
Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Cell Lysates, Tissue, Serum, Urine samples from Human, Goat, Dog

Mouse pre-microRNA Expression Construct mir-105

MMIR-105-PA-1 Bacterial Streak
EUR 684

CytoSelect 96-well Cell Migration Assay (5 ?m), Fluorometric

CBA-105 96 assays
EUR 635
Description: Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their environment. Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. CytoSelect Cell Migration Assays are ideal for determining the chemotactic properties of cells. The 5 µm pore size is ideal for monocytes / macrophages.

Human anti-Moesin IgM ELISA Kit, 96 tests, Quantitative

MSN-105 1 kit
EUR 712

Human Anti-Centromere B IgM ELISA Kit, 96 tests, Quantitative

CMB-105 1 kit
EUR 712

Monkey Stem Cell Factor (SCF) ELISA Kit, 96 tests, Quantitative

MSCF-105 1 kit
EUR 590

Mouse Transforming Growth Factor beta (TGFB) ELISA Kit, 96 tests, Quantitative

MTGF-105 1 kit
EUR 482

Human anti-Nuclear pore glycoprotein p62 IgM ELISA Kit, 96 tests, Quantitative

NUP62-105 1 Kit
EUR 712

Human CCL2 ELISA Kit, 96 tests, Quantitative

HCC-0L2-105 1 kit
EUR 482

Mouse IL-2 ELISA Kit, 96 tests, Quantitative

MIL-002-105 1 kit
EUR 482

Human IL-4 ELISA Kit, 96 tests, Quantitative

HIL-004-105 1 kit
EUR 482

CytoSelect 96-well Cell Migration Assay (5 ?m), Fluorometric

CBA-105-5 5 x 96 assays
EUR 2613
Description: Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their environment. Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. CytoSelect Cell Migration Assays are ideal for determining the chemotactic properties of cells. The 5 µm pore size is ideal for monocytes / macrophages.

Monkey Anti-dsDNA IgM ELISA Kit, 96 tests, Quantitative

670-105-DNM 1 Kit
EUR 773

Mouse Sickle tail protein (SKT) ELISA Kit

abx389166-96tests 96 tests
EUR 911

Mouse Sickle tail protein, Skt ELISA KIT

ELI-29595m 96 Tests
EUR 865

Human beta-defensin 105 (BD105) ELISA Kit, 96 tests, Quantitative

100-270-BD105 1 Kit
EUR 895

Human Anti-Yersinia enterocolitica IgM ELISA Kit, 96 tests, Qualitative

690-105-YEM 1 kit
EUR 712

DuP 105

HY-101726 10mg
EUR 6041

ACP-105

HY-112256 50mg
EUR 1025

Mouse/Rat Amyloid-beta (AB1-40) ELISA Kit, 96 tests, Quantitative

200-105-A40 1 kit
EUR 895

Human Rheumatoid Factors IgA (RF) ELISA Kit, 96 tests, Semi-Quantitative

3000-105-RFA 1 kit
EUR 590

Human Anti-Tetanus Toxin/Toxoid IgM ELISA kit, 96 tests, Quantitative

930-105-TTM 1 Kit
EUR 834

Human Sickle tail protein homolog, SKT ELISA KIT

ELI-18163h 96 Tests
EUR 824

Mouse Anti-Myelin Basic Protein (MBP) IgG ELISA Kit, 96 tests, Quantitative

630-105-MBP 1 Kit
EUR 712

Sheep Anti-Bovine Serum Albumin (BSA) IgG ELISA Kit, 96 tests, Quantitative

710-105-BSG 1 Kit
EUR 651

Mouse Anti-Ovalbumin (Gal d 2) IgG (IgG specific) ELISA Kit, 96 tests, Quantitative

600-105-OGG 1 kit
EUR 773

Mouse Anti-Anthrax Protective Antigen 83 (PA83) IgG-specific) ELISA kit, 96 tests, quantitative

900-105-83G 1 Kit
EUR 773

Mouse Anti-Japanese encephalitis virusenvelop Protein (JEV-EP) IgM ELISA kit, 96 tests, quantitative

910-105-JEM 1 Kit
EUR 841

Superior Broth™

105 500 g
EUR 114

hCRP FRET 96

CH1021-96 1 Kit
EUR 455

hCRP TRF 96

CHTR1021-96 1 Kit
EUR 482

hAlbumin FRET 96

AH1005-96 1 Kit
EUR 455

hAlbumin TRF 96

AHTR1005-96 1 Kit
EUR 482

hInsulin FRET 96

IH1017-96 1 Kit
EUR 455

hInsulin TRF 96

IHTR1017-96 1 Kit
EUR 482

rIgG FRET 96

RI1024-96 1 Kit
EUR 455

mIgG TRF 96

MIGTR1020-96 1 Kit
EUR 482

Rnase (90–105)

5-01885 4 x 1mg Ask for price

Skt ELISA Kit| Mouse Sickle tail protein ELISA Kit

EF014796 96 Tests
EUR 689

Medium 199/BCDB 105

C0012-02 RT 500 mL Bottle
EUR 151

Leptin (93-105) (human)

5-01448 4 x 5mg Ask for price

Leptin (93-105) Peptide

20-abx265126
  • EUR 495.00
  • EUR 829.00
  • EUR 370.00
  • 10 mg
  • 25 mg
  • 5 mg

HIST1H1C (Ab-105) Antibody

1-CSB-PA010378OA105nme1HU
  • EUR 332.00
  • EUR 335.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against HIST1H1C (Ab-105). Recognizes HIST1H1C (Ab-105) from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IF; Recommended dilution: IF:1:50-1:200

Leptin (93-105) (human)

H-3426.0001 1.0mg
EUR 151
Description: Sum Formula: C64H110N20O23; CAS# [200436-43-7]

Leptin (93-105) (human)

H-3426.0005 5.0mg
EUR 515
Description: Sum Formula: C64H110N20O23; CAS# [200436-43-7]

rno-miR-105 Primers

MP-r00269 150 ul / 10 uM
EUR 176

hsa-miR-105 Primers

MPH01019 150 ul / 10 uM
EUR 121

mmu-miR-105 Primers

MPM00020 150 ul / 10 uM
EUR 121

Rat Coiled coil domain containing protein 105(CCDC105) ELISA kit

E02C1008-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Rat Coiled coil domain containing protein 105(CCDC105) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Coiled coil domain containing protein 105(CCDC105) ELISA kit

E03C1008-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Mouse Coiled coil domain containing protein 105(CCDC105) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Coiled coil domain containing protein 105(CCDC105) ELISA kit

E08C1008-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Canine Coiled coil domain containing protein 105(CCDC105) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Coiled coil domain containing protein 105(CCDC105) ELISA kit

E06C1008-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Goat Coiled coil domain containing protein 105(CCDC105) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Coiled coil domain containing protein 105(CCDC105) ELISA kit

E04C1008-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Rabbit Coiled coil domain containing protein 105(CCDC105) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Coiled coil domain containing protein 105(CCDC105) ELISA kit

E07C1008-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Porcine Coiled coil domain containing protein 105(CCDC105) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Coiled coil domain containing protein 105(CCDC105) ELISA kit

E01C1008-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Human Coiled coil domain containing protein 105(CCDC105) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Coiled coil domain containing protein 105(CCDC105) ELISA kit

E09C1008-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Monkey Coiled coil domain containing protein 105(CCDC105) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

HSC70 ELISA Kit

SKT-106-96 1 plate of 96 wells
EUR 717
Description: Sandwich ELISA kit used for quantitate HSC70 concentration in Cell Lysates, Tissue, Serum, Whole Blood samples from Human, Avian

HSP90 alpha ELISA Kit

SKT-107-96 1 plate of 96 wells
EUR 685
Description: Sandwich ELISA kit used for quantitate HSP90 alpha concentration in Cell Lysates, Tissue, Serum, Whole Blood samples from Human, Goat, Avian

HSP70 ELISA Kit (High-Sensitivity)

SKT-108-96 1 plate of 96 wells
EUR 685
Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Serum, Plasma, Cell Lysates, Tissue samples from Human, Monkey, Dog, Rat, Mouse

HSP27 ELISA Kit

SKT-109-96 1 plate of 96 wells
EUR 585
Description: Sandwich ELISA kit used for quantitate HSP27 concentration in Serum, Plasma, Cell Lysates, Tissue samples from Human

HSP60 ELISA Kit

SKT-110-96 1 plate of 96 wells
EUR 585
Description: Sandwich ELISA kit used for quantitate HSP60 concentration in Cell Lysates, Tissue, Serum samples from Human

HO-1 ELISA Kit

SKT-111-96 1 plate of 96 wells
EUR 585
Description: Sandwich ELISA kit used for quantitate HO-1 concentration in Cell Lysates, Tissue, Serum, Cyst fluid samples from Human, Rat

HSP65 ELISA Kit

SKT-113-96 1 plate of 96 wells
EUR 633
Description: Sandwich ELISA kit used for quantitate M bovis/M tuberculosum HSP65 concentration in human samples in Cell Lysates, Tissue, Serum samples from M bovis, M tuberculosum

Alpha B Crystallin ELISA Kit

SKT-123-96 1 plate of 96 wells
EUR 717
Description: Sandwich ELISA kit used for quantitate alpha B crystallin concentration in Cell Lysates, Tissue, Serum samples from Human

HSP70 ELISA Kit (PLANT)

SKT-124-96 1 plate of 96 wells
EUR 717
Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Plant extract, Cell Lysates, Tissue, Serum, Plasma samples from Plant, Human

Nitrotyrosine ELISA Kit

SKT-126-96 1 plate of 96 wells
EUR 460
Description: Competitive ELISA kit used for quantitate Nitrotyrosine in Plasma, Serum, Cell Lysates, Urine samples from all species

Rat GRP78 ELISA Kit

SKT-137-96 1 plate of 96 wells
EUR 632
Description: Sandwich ELISA kit used for quantitate GRP78 concentration in rat samples in Tissue samples from Rat

Dibromo-tyrosine ELISA Kit

SKT-140-96 1 plate of 96 wells
EUR 566
Description: Competitive ELISA kit used to quantify free and protein-bound 3,5-dibromotyrosine in Plasma, Urine samples from all species

Cortisol EIA Kit

SKT-201-96 1 plate of 96 wells
EUR 329
Description: Competitive EIA kit used for quantitative measuring cortisol present in Dried Fecal Samples, Saliva, Urine, Serum, EDTA Plasma, Heparin Plasma, Tissue Culture Media samples from all species

Glutathione Detection Kit

SKT-202-96 1 plate of 96 wells
EUR 428
Description: Direct Fluorometric detection assay to measure the total GSH content in Whole Blood, Serum, EDTA Plasma, Heparin Plasma, Erythrocytes, Urine, Cell Lysates, Tissue samples from all species

Glutathione S-Transferase Activity Kit

SKT-203-96 1 plate of 96 wells
EUR 428
Description: Enzyme Activity Fluorometric assay used for quantitative measuring the activity of glutathione S-transferase in Urine, Serum, EDTA Plasma, Heparin Plasma, Cell Lysates samples from Human, Mollusk, Fish

Glutathione Reductase Activity Kit

SKT-204-96 1 plate of 96 wells
EUR 428
Description: Enzyme Activity Fluorometric assay used for measuring glutathione reductase activity by the amount of GSH generated from the reduction of GSSG, in Serum, EDTA Plasma, Heparin Plasma, Erythrocytes, Cell Lysates samples from Human

Corticosterone EIA Kit

SKT-205-96 1 plate of 96 wells
EUR 355
Description: Sandwich EIA kit used to measure the corticosterone present in Serum, EDTA Plasma, Heparin Plasma, Urine, Tissue Culture Media, Dried Fecal Samples samples from all species

Cortisone CLIA Kit

SKT-206-96 1 plate of 96 wells
EUR 467
Description: Sandwich CLIA kit used for quantitative measuring the cortisone present in Dried Fecal Samples, Serum, Saliva, Urine, Plasma, Tissue Culture Media samples from all species

Prostaglandin E2 EIA Kit

SKT-207-96 1 plate of 96 wells
EUR 527
Description: Sandwich EIA kit used for quantitative measuring PGE2 present in Saliva, Urine, Serum, EDTA Plasma, Heparin Plasma, Tissue Culture Media samples from all species

Cyclic AMP CLIA Kit (High-Sensitivity)

SKT-208-96 1 plate of 96 wells
EUR 494
Description: Direct CLIA kit used for quantitative measuring cAMP present in Cell Lysates, Tissue, Saliva, Urine, EDTA Plasma, Heparin Plasma, Tissue Culture Media samples from all species

Cyclic AMP EIA Kit

SKT-209-96 1 plate of 96 wells
EUR 454
Description: Direct EIA kit used for quantitative measuring cAMP present in Cell Lysates, Tissue, Saliva, Urine, EDTA Plasma, Heparin Plasma, Tissue Culture Media samples from all species

Cyclic GMP CLIA Kit (High-Sensitivity)

SKT-210-96 1 plate of 96 wells
EUR 520
Description: Direct CLIA kit used to measure cGMP present in Cell Lysates, Tissue, Saliva, Urine, EDTA Plasma, Tissue Culture Media samples from all species

Cyclic GMP EIA Kit

SKT-211-96 1 plate of 96 wells
EUR 474
Description: Direct EIA kit used for quantitative measuring cGMP present in Cell Lysates, Tissue, Saliva, Urine, EDTA Plasma, Tissue Culture Media samples from all species

Nitric Oxide Detection Kit

SKT-212-96 2 plates of 96 wells
EUR 342
Description: Indirect Colorimetric assay used for quantitative measuring Nitrate and Nitrite present in a variety of samples in Serum, Plasma, Urine, Saliva, Water, Buffer, Cell Lysates, Tissue Culture Media samples from all species

Retinol Binding Protein Urinary EIA Kit

SKT-218-96 1 plate of 96 wells
EUR 527
Description: Sandwich EIA kit used to measure RBP levels in urine samples in Urine samples from Human, Rat, Dog, Monkey

Cystatin C EIA Kit

SKT-219-96 1 plate of 96 wells
EUR 494
Description: Sandwich EIA kit used to measure cystatin C levels in Serum, EDTA Plasma, Heparin Plasma, Urine, Tissue Culture Media samples from Human

Mouse Anti-S. Pneumococcal vaccine (Prevnar-7/PCV-7) IgM ELISA Kit; (7 serotypes: 4,6B,9V,14,18C,19F, and 23F), 96 tests, quantitative

560-105-07M 1 Kit
EUR 834

Tissue Culture Plate, 96 Well

TCP20-96 1 UNIT
EUR 53.48

Aligned Nanofibers 96 Well Plate

3D00012-96 700 nm-PCLs
EUR 110

Bridge-It cAMP-PDE 96

PD1016-96 1 Kit
EUR 455

Recombinant RuV E2 Protein (aa 31-105) [His] (aa 31-105)

VAng-Lsx0492-100g 100 µg
EUR 594
Description: RuV E2 Protein (aa 31-105) [His], recombinant protein from E. coli.

Guinea pig Coiled coil domain containing protein 105(CCDC105) ELISA kit

E05C1008-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Guinea pig Coiled coil domain containing protein 105(CCDC105) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Lymphocyte Antigen 96 ELISA kit

E07L0307-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Porcine Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Lymphocyte Antigen 96 ELISA kit

E08L0307-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Canine Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Lymphocyte Antigen 96 ELISA kit

E04L0307-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Rabbit Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Lymphocyte Antigen 96 ELISA kit

E06L0307-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Goat Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Lymphocyte Antigen 96 ELISA kit

E03L0307-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Mouse Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Lymphocyte Antigen 96 ELISA kit

E02L0307-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Rat Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Lymphocyte Antigen 96 ELISA kit

E01L0307-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Human Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Lymphocyte Antigen 96 ELISA kit

E09L0307-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Monkey Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Consistent with its pharmacologic properties, brief interruptions of baricitinib during phase 3 studies were associated with minor increases in RA symptoms that resolved following retreatment. This analysis provides useful information for clinicians, as temporary interruption of antirheumatic therapy is common in the care of patients with RA.ClinicalTrials.gov; NCT01710358, NCT01711359, NCT01721057, NCT01721044.