In clinical practice, temporary interruption of rheumatoid arthritis (RA) therapy is common for various reasons including side effects, non-compliance, or necessity for surgery. To characterize temporary interruptions of baricitinib and placebo-matched tablets in phase 3 studies of patients with moderate-to-severe rheumatoid arthritis (RA) and describe their impact on efficacy and safety.

During 4 baricitinib phase 3 studies, investigators documented timing, reason, and duration of investigator-initiated temporary interruptions of study drug. In 2 studies, patients recorded RA symptoms in daily diaries for 12 weeks.

Post hoc analyses investigated changes in symptom scores during interruptions and resumption of treatment. Interruptions were evaluated for reoccurrence of adverse events or laboratory abnormalities after retreatment.

Across the placebo-controlled studies, interruptions occurred in larger proportions of baricitinib- (2 mg, 18%; 4 mg, 18%) vs placebo-treated (9%) patients in only one study (bDMARD-inadequate responder patients, RA-BEACON). In the active comparator-controlled studies, the lowest rates of interruption were in the baricitinib monotherapy arm (9%) of RA-BEGIN (vs methotrexate monotherapy or combination therapy), and proportions were similar for baricitinib (10%) and adalimumab (9%) in RA-BEAM.

Adverse events were the most common reason for interruption, but their reoccurrence after drug restart was infrequent. Most interruptions lasted ≤ 2 weeks. Daily diaries indicated modest symptom increases during interruption with return to pre-interruption levels or better after resumption. Interruptions had no impact on long-term efficacy outcomes.

HSP70 ELISA Kit
SKT-105-480	Stressmarq	5 plates of 96 wells	EUR 2260
Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Cell Lysates, Tissue, Serum, Urine samples from Human, Goat, Dog

Mouse pre-microRNA Expression Construct mir-105
MMIR-105-PA-1	SBI	Bacterial Streak	EUR 684

CytoSelect 96-well Cell Migration Assay (5 ?m), Fluorometric
CBA-105	Cell Biolabs	96 assays	EUR 635
Description: Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their environment. Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. CytoSelect Cell Migration Assays are ideal for determining the chemotactic properties of cells. The 5 µm pore size is ideal for monocytes / macrophages.

Human anti-Moesin IgM ELISA Kit, 96 tests, Quantitative
MSN-105	Alpha Diagnostics	1 kit	EUR 712

Human Anti-Centromere B IgM ELISA Kit, 96 tests, Quantitative
CMB-105	Alpha Diagnostics	1 kit	EUR 712

Monkey Stem Cell Factor (SCF) ELISA Kit, 96 tests, Quantitative
MSCF-105	Alpha Diagnostics	1 kit	EUR 590

Mouse Transforming Growth Factor beta (TGFB) ELISA Kit, 96 tests, Quantitative
MTGF-105	Alpha Diagnostics	1 kit	EUR 482

Human anti-Nuclear pore glycoprotein p62 IgM ELISA Kit, 96 tests, Quantitative
NUP62-105	Alpha Diagnostics	1 Kit	EUR 712

Human CCL2 ELISA Kit, 96 tests, Quantitative
HCC-0L2-105	Alpha Diagnostics	1 kit	EUR 482

Mouse IL-2 ELISA Kit, 96 tests, Quantitative
MIL-002-105	Alpha Diagnostics	1 kit	EUR 482

Human IL-4 ELISA Kit, 96 tests, Quantitative
HIL-004-105	Alpha Diagnostics	1 kit	EUR 482

CytoSelect 96-well Cell Migration Assay (5 ?m), Fluorometric
CBA-105-5	Cell Biolabs	5 x 96 assays	EUR 2613
Description: Chemotaxis describes the movement of cells toward or away from a chemical stimulus in their environment. Cell chemotaxis plays a pivotal role in the progression of cancer and other diseases. CytoSelect Cell Migration Assays are ideal for determining the chemotactic properties of cells. The 5 µm pore size is ideal for monocytes / macrophages.

Monkey Anti-dsDNA IgM ELISA Kit, 96 tests, Quantitative
670-105-DNM	Alpha Diagnostics	1 Kit	EUR 773

Mouse Sickle tail protein (SKT) ELISA Kit
abx389166-96tests	Abbexa	96 tests	EUR 911

Mouse Sickle tail protein, Skt ELISA KIT
ELI-29595m	Lifescience Market	96 Tests	EUR 865

Human beta-defensin 105 (BD105) ELISA Kit, 96 tests, Quantitative
100-270-BD105	Alpha Diagnostics	1 Kit	EUR 895

Human Anti-Yersinia enterocolitica IgM ELISA Kit, 96 tests, Qualitative
690-105-YEM	Alpha Diagnostics	1 kit	EUR 712

DuP 105
HY-101726	MedChemExpress	10mg	EUR 6041

ACP-105
HY-112256	MedChemExpress	50mg	EUR 1025

Mouse/Rat Amyloid-beta (AB1-40) ELISA Kit, 96 tests, Quantitative
200-105-A40	Alpha Diagnostics	1 kit	EUR 895

Human Rheumatoid Factors IgA (RF) ELISA Kit, 96 tests, Semi-Quantitative
3000-105-RFA	Alpha Diagnostics	1 kit	EUR 590

Human Anti-Tetanus Toxin/Toxoid IgM ELISA kit, 96 tests, Quantitative
930-105-TTM	Alpha Diagnostics	1 Kit	EUR 834

Human Sickle tail protein homolog, SKT ELISA KIT
ELI-18163h	Lifescience Market	96 Tests	EUR 824

Mouse Anti-Myelin Basic Protein (MBP) IgG ELISA Kit, 96 tests, Quantitative
630-105-MBP	Alpha Diagnostics	1 Kit	EUR 712

Sheep Anti-Bovine Serum Albumin (BSA) IgG ELISA Kit, 96 tests, Quantitative
710-105-BSG	Alpha Diagnostics	1 Kit	EUR 651

Mouse Anti-Ovalbumin (Gal d 2) IgG (IgG specific) ELISA Kit, 96 tests, Quantitative
600-105-OGG	Alpha Diagnostics	1 kit	EUR 773

Mouse Anti-Anthrax Protective Antigen 83 (PA83) IgG-specific) ELISA kit, 96 tests, quantitative
900-105-83G	Alpha Diagnostics	1 Kit	EUR 773

Mouse Anti-Japanese encephalitis virusenvelop Protein (JEV-EP) IgM ELISA kit, 96 tests, quantitative
910-105-JEM	Alpha Diagnostics	1 Kit	EUR 841

Superior Broth™
105	AthenaES	500 g	EUR 114

hCRP FRET 96
CH1021-96	Mediomics	1 Kit	EUR 455

hCRP TRF 96
CHTR1021-96	Mediomics	1 Kit	EUR 482

hAlbumin FRET 96
AH1005-96	Mediomics	1 Kit	EUR 455

hAlbumin TRF 96
AHTR1005-96	Mediomics	1 Kit	EUR 482

hInsulin FRET 96
IH1017-96	Mediomics	1 Kit	EUR 455

hInsulin TRF 96
IHTR1017-96	Mediomics	1 Kit	EUR 482

rIgG FRET 96
RI1024-96	Mediomics	1 Kit	EUR 455

mIgG TRF 96
MIGTR1020-96	Mediomics	1 Kit	EUR 482

Rnase (90–105)
5-01885	CHI Scientific	4 x 1mg	Ask for price

Skt ELISA Kit| Mouse Sickle tail protein ELISA Kit
EF014796	Lifescience Market	96 Tests	EUR 689

Medium 199/BCDB 105
C0012-02	Addexbio	RT 500 mL Bottle	EUR 151

Leptin (93-105) (human)
5-01448	CHI Scientific	4 x 5mg	Ask for price

Leptin (93-105) Peptide
20-abx265126	Abbexa	EUR 495.00 EUR 829.00 EUR 370.00	10 mg 25 mg 5 mg

HIST1H1C (Ab-105) Antibody
1-CSB-PA010378OA105nme1HU	Cusabio	EUR 332.00 EUR 335.00	100ul 50ul
Description: A polyclonal antibody against HIST1H1C (Ab-105). Recognizes HIST1H1C (Ab-105) from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IF; Recommended dilution: IF:1:50-1:200

Leptin (93-105) (human)
H-3426.0001	Bachem	1.0mg	EUR 151
Description: Sum Formula: C64H110N20O23; CAS# [200436-43-7]

Leptin (93-105) (human)
H-3426.0005	Bachem	5.0mg	EUR 515
Description: Sum Formula: C64H110N20O23; CAS# [200436-43-7]

rno-miR-105 Primers
MP-r00269	ABM	150 ul / 10 uM	EUR 176

hsa-miR-105 Primers
MPH01019	ABM	150 ul / 10 uM	EUR 121

mmu-miR-105 Primers
MPM00020	ABM	150 ul / 10 uM	EUR 121

Rat Coiled coil domain containing protein 105(CCDC105) ELISA kit
E02C1008-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Rat Coiled coil domain containing protein 105(CCDC105) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Coiled coil domain containing protein 105(CCDC105) ELISA kit
E03C1008-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Mouse Coiled coil domain containing protein 105(CCDC105) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Coiled coil domain containing protein 105(CCDC105) ELISA kit
E08C1008-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Canine Coiled coil domain containing protein 105(CCDC105) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Coiled coil domain containing protein 105(CCDC105) ELISA kit
E06C1008-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Goat Coiled coil domain containing protein 105(CCDC105) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Coiled coil domain containing protein 105(CCDC105) ELISA kit
E04C1008-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Rabbit Coiled coil domain containing protein 105(CCDC105) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Coiled coil domain containing protein 105(CCDC105) ELISA kit
E07C1008-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Porcine Coiled coil domain containing protein 105(CCDC105) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Coiled coil domain containing protein 105(CCDC105) ELISA kit
E01C1008-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Human Coiled coil domain containing protein 105(CCDC105) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Coiled coil domain containing protein 105(CCDC105) ELISA kit
E09C1008-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Monkey Coiled coil domain containing protein 105(CCDC105) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

HSC70 ELISA Kit
SKT-106-96	Stressmarq	1 plate of 96 wells	EUR 717
Description: Sandwich ELISA kit used for quantitate HSC70 concentration in Cell Lysates, Tissue, Serum, Whole Blood samples from Human, Avian

HSP90 alpha ELISA Kit
SKT-107-96	Stressmarq	1 plate of 96 wells	EUR 685
Description: Sandwich ELISA kit used for quantitate HSP90 alpha concentration in Cell Lysates, Tissue, Serum, Whole Blood samples from Human, Goat, Avian

HSP70 ELISA Kit (High-Sensitivity)
SKT-108-96	Stressmarq	1 plate of 96 wells	EUR 685
Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Serum, Plasma, Cell Lysates, Tissue samples from Human, Monkey, Dog, Rat, Mouse

HSP27 ELISA Kit
SKT-109-96	Stressmarq	1 plate of 96 wells	EUR 585
Description: Sandwich ELISA kit used for quantitate HSP27 concentration in Serum, Plasma, Cell Lysates, Tissue samples from Human

HSP60 ELISA Kit
SKT-110-96	Stressmarq	1 plate of 96 wells	EUR 585
Description: Sandwich ELISA kit used for quantitate HSP60 concentration in Cell Lysates, Tissue, Serum samples from Human

HO-1 ELISA Kit
SKT-111-96	Stressmarq	1 plate of 96 wells	EUR 585
Description: Sandwich ELISA kit used for quantitate HO-1 concentration in Cell Lysates, Tissue, Serum, Cyst fluid samples from Human, Rat

HSP65 ELISA Kit
SKT-113-96	Stressmarq	1 plate of 96 wells	EUR 633
Description: Sandwich ELISA kit used for quantitate M bovis/M tuberculosum HSP65 concentration in human samples in Cell Lysates, Tissue, Serum samples from M bovis, M tuberculosum

Alpha B Crystallin ELISA Kit
SKT-123-96	Stressmarq	1 plate of 96 wells	EUR 717
Description: Sandwich ELISA kit used for quantitate alpha B crystallin concentration in Cell Lysates, Tissue, Serum samples from Human

HSP70 ELISA Kit (PLANT)
SKT-124-96	Stressmarq	1 plate of 96 wells	EUR 717
Description: Sandwich ELISA kit used for quantitate HSP70 concentration in Plant extract, Cell Lysates, Tissue, Serum, Plasma samples from Plant, Human

Nitrotyrosine ELISA Kit
SKT-126-96	Stressmarq	1 plate of 96 wells	EUR 460
Description: Competitive ELISA kit used for quantitate Nitrotyrosine in Plasma, Serum, Cell Lysates, Urine samples from all species

Rat GRP78 ELISA Kit
SKT-137-96	Stressmarq	1 plate of 96 wells	EUR 632
Description: Sandwich ELISA kit used for quantitate GRP78 concentration in rat samples in Tissue samples from Rat

Dibromo-tyrosine ELISA Kit
SKT-140-96	Stressmarq	1 plate of 96 wells	EUR 566
Description: Competitive ELISA kit used to quantify free and protein-bound 3,5-dibromotyrosine in Plasma, Urine samples from all species

Cortisol EIA Kit
SKT-201-96	Stressmarq	1 plate of 96 wells	EUR 329
Description: Competitive EIA kit used for quantitative measuring cortisol present in Dried Fecal Samples, Saliva, Urine, Serum, EDTA Plasma, Heparin Plasma, Tissue Culture Media samples from all species

Glutathione Detection Kit
SKT-202-96	Stressmarq	1 plate of 96 wells	EUR 428
Description: Direct Fluorometric detection assay to measure the total GSH content in Whole Blood, Serum, EDTA Plasma, Heparin Plasma, Erythrocytes, Urine, Cell Lysates, Tissue samples from all species

Glutathione S-Transferase Activity Kit
SKT-203-96	Stressmarq	1 plate of 96 wells	EUR 428
Description: Enzyme Activity Fluorometric assay used for quantitative measuring the activity of glutathione S-transferase in Urine, Serum, EDTA Plasma, Heparin Plasma, Cell Lysates samples from Human, Mollusk, Fish

Glutathione Reductase Activity Kit
SKT-204-96	Stressmarq	1 plate of 96 wells	EUR 428
Description: Enzyme Activity Fluorometric assay used for measuring glutathione reductase activity by the amount of GSH generated from the reduction of GSSG, in Serum, EDTA Plasma, Heparin Plasma, Erythrocytes, Cell Lysates samples from Human

Corticosterone EIA Kit
SKT-205-96	Stressmarq	1 plate of 96 wells	EUR 355
Description: Sandwich EIA kit used to measure the corticosterone present in Serum, EDTA Plasma, Heparin Plasma, Urine, Tissue Culture Media, Dried Fecal Samples samples from all species

Cortisone CLIA Kit
SKT-206-96	Stressmarq	1 plate of 96 wells	EUR 467
Description: Sandwich CLIA kit used for quantitative measuring the cortisone present in Dried Fecal Samples, Serum, Saliva, Urine, Plasma, Tissue Culture Media samples from all species

Prostaglandin E2 EIA Kit
SKT-207-96	Stressmarq	1 plate of 96 wells	EUR 527
Description: Sandwich EIA kit used for quantitative measuring PGE2 present in Saliva, Urine, Serum, EDTA Plasma, Heparin Plasma, Tissue Culture Media samples from all species

Cyclic AMP CLIA Kit (High-Sensitivity)
SKT-208-96	Stressmarq	1 plate of 96 wells	EUR 494
Description: Direct CLIA kit used for quantitative measuring cAMP present in Cell Lysates, Tissue, Saliva, Urine, EDTA Plasma, Heparin Plasma, Tissue Culture Media samples from all species

Cyclic AMP EIA Kit
SKT-209-96	Stressmarq	1 plate of 96 wells	EUR 454
Description: Direct EIA kit used for quantitative measuring cAMP present in Cell Lysates, Tissue, Saliva, Urine, EDTA Plasma, Heparin Plasma, Tissue Culture Media samples from all species

Cyclic GMP CLIA Kit (High-Sensitivity)
SKT-210-96	Stressmarq	1 plate of 96 wells	EUR 520
Description: Direct CLIA kit used to measure cGMP present in Cell Lysates, Tissue, Saliva, Urine, EDTA Plasma, Tissue Culture Media samples from all species

Cyclic GMP EIA Kit
SKT-211-96	Stressmarq	1 plate of 96 wells	EUR 474
Description: Direct EIA kit used for quantitative measuring cGMP present in Cell Lysates, Tissue, Saliva, Urine, EDTA Plasma, Tissue Culture Media samples from all species

Nitric Oxide Detection Kit
SKT-212-96	Stressmarq	2 plates of 96 wells	EUR 342
Description: Indirect Colorimetric assay used for quantitative measuring Nitrate and Nitrite present in a variety of samples in Serum, Plasma, Urine, Saliva, Water, Buffer, Cell Lysates, Tissue Culture Media samples from all species

Retinol Binding Protein Urinary EIA Kit
SKT-218-96	Stressmarq	1 plate of 96 wells	EUR 527
Description: Sandwich EIA kit used to measure RBP levels in urine samples in Urine samples from Human, Rat, Dog, Monkey

Cystatin C EIA Kit
SKT-219-96	Stressmarq	1 plate of 96 wells	EUR 494
Description: Sandwich EIA kit used to measure cystatin C levels in Serum, EDTA Plasma, Heparin Plasma, Urine, Tissue Culture Media samples from Human

Mouse Anti-S. Pneumococcal vaccine (Prevnar-7/PCV-7) IgM ELISA Kit; (7 serotypes: 4,6B,9V,14,18C,19F, and 23F), 96 tests, quantitative
560-105-07M	Alpha Diagnostics	1 Kit	EUR 834

Tissue Culture Plate, 96 Well
TCP20-96	Bio Basic	1 UNIT	EUR 53.48

Aligned Nanofibers 96 Well Plate
3D00012-96	Neuromics	700 nm-PCLs	EUR 110

Bridge-It cAMP-PDE 96
PD1016-96	Mediomics	1 Kit	EUR 455

Recombinant RuV E2 Protein (aa 31-105) [His] (aa 31-105)
VAng-Lsx0492-100g	Creative Biolabs	100 µg	EUR 594
Description: RuV E2 Protein (aa 31-105) [His], recombinant protein from E. coli.

Guinea pig Coiled coil domain containing protein 105(CCDC105) ELISA kit
E05C1008-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Guinea pig Coiled coil domain containing protein 105(CCDC105) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Lymphocyte Antigen 96 ELISA kit
E07L0307-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Porcine Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Lymphocyte Antigen 96 ELISA kit
E08L0307-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Canine Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Lymphocyte Antigen 96 ELISA kit
E04L0307-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Rabbit Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Lymphocyte Antigen 96 ELISA kit
E06L0307-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Goat Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Lymphocyte Antigen 96 ELISA kit
E03L0307-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Mouse Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Lymphocyte Antigen 96 ELISA kit
E02L0307-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Rat Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Lymphocyte Antigen 96 ELISA kit
E01L0307-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Human Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Lymphocyte Antigen 96 ELISA kit
E09L0307-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Monkey Lymphocyte Antigen 96 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Consistent with its pharmacologic properties, brief interruptions of baricitinib during phase 3 studies were associated with minor increases in RA symptoms that resolved following retreatment. This analysis provides useful information for clinicians, as temporary interruption of antirheumatic therapy is common in the care of patients with RA.ClinicalTrials.gov; NCT01710358, NCT01711359, NCT01721057, NCT01721044.