With the second largest tuberculosis (TB) burden globally, China is committed to actively engage in international TB clinical trials to contribute to global TB research. However, lack of research capacity among local sites has been identified as a barrier.
The China Tuberculosis Clinical Trials Consortium (CTCTC) was initiated by Beijing Chest Hospital with investment from the US National Institutes of Health and technical support from Family Health International 360 in 2013, as a nationwide collaborative clinical trial network to strengthen selected clinical site research capacity and attract TB clinical trials.
The program aims to: 1) recruit leading hospitals that care for TB patients; 2) conduct on-site assessment to identify capacity gaps and needs for improvement; 3) design and deliver capacity building activities; 4) attract and deliver high quality results for TB clinical trials.
A total of 24 sites have joined CTCTC, covering 20 provinces in China. Twenty-two sites have been accredited by the National Medical Products Administration (NMPA) to be qualified to conduct TB clinical trials. The onsite assessment, extensive trainings among the CTCTC sites and young investigators have resulted in better understanding and improvement of the site capacity in conducting TB clinical trials.
The establishment and growth of the CTCTC network has benefited from the good leadership, effective international cooperation and local commitment.
Amplite™ Colorimetric Malondialdehyde (MDA) Quantitation Kit |
10070 |
AAT Bioquest |
200 Tests |
EUR 350 |
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Amplite™ Fluorimetric Malondialdehyde (MDA) Quantitation Kit |
10071 |
AAT Bioquest |
200 Tests |
EUR 350 |
|
Amplite™ Colorimetric α-Ketoglutarate Quantitation Kit |
10085 |
AAT Bioquest |
200 Tests |
EUR 393 |
|
Amplite™ Fluorimetric α-Ketoglutarate Quantitation Kit |
10087 |
AAT Bioquest |
200 Tests |
EUR 393 |
|
iFluor™ 610 succinimidyl ester |
1038 |
AAT Bioquest |
1 mg |
EUR 219 |
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iFluor™ 546 succinimidyl ester |
1048 |
AAT Bioquest |
1 mg |
EUR 219 |
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iFluor™ 568 succinimidyl ester |
1049 |
AAT Bioquest |
1 mg |
EUR 219 |
|
ReadiUse™ ABTS Substrate Solution *Optimized for ELISA Assays with HRP Conjugates* |
11001 |
AAT Bioquest |
1 L |
EUR 202 |
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ReadiUse™ TMB Substrate Solution *Optimized for ELISA Assays with HRP Conjugates* |
11003 |
AAT Bioquest |
1 L |
EUR 480 |
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ReadiUse™ hydrogen peroxide solution *50 mM calibrated and stabilized solution* |
11004 |
AAT Bioquest |
5x10 mL |
EUR 132 |
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ReadiUse™ TMB Substrate Solution *Optimized for ELISA Assays with HRP Conjugates* |
11012 |
AAT Bioquest |
100 ml |
EUR 115 |
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ReadiLink™ Rapid mFluor™ Violet 420 Antibody Labeling Kit *Microscale Optimized for Labeling 50 µg Antibody Per Reaction* |
1105 |
AAT Bioquest |
2 Labelings |
EUR 176 |
|
Luminol [3-Aminophthalhydrazide] *CAS 521-31-3* |
11050 |
AAT Bioquest |
1 g |
EUR 115 |
|
Amplite™ Fluorimetric Fluorescamine Protein Quantitation Kit *Blue Fluorescence* |
11100 |
AAT Bioquest |
200 Tests |
EUR 219 |
|
Amplite™ Fluorimetric Protein Quantitation Kit *Orange Fluorescence* |
11105 |
AAT Bioquest |
500 tests |
EUR 219 |
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ReadiLink™ Rapid mFluor™ Violet 540 Antibody Labeling Kit *Microscale Optimized for Labeling 50 µg Antibody Per Reaction* |
1114 |
AAT Bioquest |
2 Labelings |
EUR 176 |
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ReadiLink™ Rapid mFluor™ Blue 570 Antibody Labeling Kit *Microscale Optimized for Labeling 50 µg Antibody Per Reaction* |
1120 |
AAT Bioquest |
2 Labelings |
EUR 176 |
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ReadiLink™ Rapid mFluor™ Green 620 Antibody Labeling Kit *Microscale Optimized for Labeling 50 µg Antibody Per Reaction* |
1123 |
AAT Bioquest |
2 Labelings |
EUR 176 |
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ReadiLink™ Rapid mFluor™ Yellow 630 Antibody Labeling Kit *Microscale Optimized for Labeling 50 µg Antibody Per Reaction* |
1126 |
AAT Bioquest |
2 Labelings |
EUR 50 |
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Amplite™ Colorimetric Glucose Oxidase Assay Kit |
11299 |
AAT Bioquest |
500 Tests |
EUR 306 |
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ReadiLink™ Rapid mFluor™ Red 700 Antibody Labeling Kit *Microscale Optimized for Labeling 50 µg Antibody Per Reaction* |
1130 |
AAT Bioquest |
2 Labelings |
EUR 176 |
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Amplite™ Fluorimetric Glucose Oxidase Assay Kit *Red Fluorescence* |
11300 |
AAT Bioquest |
500 Tests |
EUR 219 |
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Amplite™ Fluorimetric Myeloperoxidase Assay Kit *Red Fluorescence* |
11301 |
AAT Bioquest |
200 Tests |
EUR 219 |
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Amplite™ Fluorimetric Glutamate Oxidase Assay Kit *Red Fluorescence* |
11302 |
AAT Bioquest |
200 Tests |
EUR 219 |
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Amplite™ Fluorimetric Monoamine Oxidase Assay Kit *Red Fluorescence* |
11303 |
AAT Bioquest |
200 Tests |
EUR 219 |
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Amplite™ Fluorimetric Xanthine Oxidase Assay Kit *Red Fluorescence* |
11304 |
AAT Bioquest |
200 Tests |
EUR 219 |
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Amplite™ Colorimetric Superoxide Dismutase (SOD) Assay Kit |
11305 |
AAT Bioquest |
200 Tests |
EUR 219 |
|
Amplite™ Fluorimetric Catalase Assay Kit *Red Fluorescence* |
11306 |
AAT Bioquest |
200 Tests |
EUR 219 |
|
Amplite™ Colorimetric Xanthine Oxidase Assay Kit |
11307 |
AAT Bioquest |
200 Tests |
EUR 219 |
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Amplite™ Colorimetric Acetylcholinesterase Assay Kit |
11400 |
AAT Bioquest |
200 Tests |
EUR 219 |
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Amplite™ Fluorimetric Acetylcholinesterase Assay Kit *Green Fluorescence* |
11401 |
AAT Bioquest |
200 Tests |
EUR 219 |
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Amplite™ Fluorimetric Acetylcholinesterase Assay Kit *Red Fluorescence* |
11402 |
AAT Bioquest |
200 Tests |
EUR 219 |
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Amplite™ Fluorimetric Acetylcholine Assay Kit *Red Fluorescence* |
11403 |
AAT Bioquest |
200 Tests |
EUR 219 |
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Cell Meter™ Intracellular Fluorimetric Hydrogen Peroxide Assay Kit *Green Fluorescence* |
11503 |
AAT Bioquest |
200 Tests |
EUR 263 |
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Cell Meter™ Intracellular Fluorimetric Hydrogen Peroxide Assay Kit *Blue Fluorescence* |
11504 |
AAT Bioquest |
100 Tests |
EUR 263 |
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Cell Meter™ Intracellular Fluorimetric Hydrogen Peroxide Assay Kit *Blue Fluorescence Optimized for Flow Cytometry* |
11505 |
AAT Bioquest |
100 Tests |
EUR 263 |
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Cell Meter™ Intracellular Fluorimetric Hydrogen Peroxide Assay Kit *Green Fluorescence Optimized for Flow Cytometry* |
11506 |
AAT Bioquest |
100 Tests |
EUR 263 |
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Amplite™ Fluorimetric Goat Anti-Mouse IgG-HRP Conjugate ELISA Assay Kit *Red Fluorescence* |
11540 |
AAT Bioquest |
1000 Tests |
EUR 219 |
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Amplite™ Fluorimetric Goat Anti-Rabbit IgG-HRP Conjugate ELISA Assay Kit *Red Fluorescence* |
11541 |
AAT Bioquest |
1000 Tests |
EUR 219 |
|
Amplite™ Colorimetric Peroxidase (HRP) Assay Kit *Blue Color* |
11551 |
AAT Bioquest |
500 Tests |
EUR 219 |
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Amplite™ Fluorimetric Peroxidase (HRP) Assay Kit *Red Fluorescence* |
11552 |
AAT Bioquest |
500 Tests |
EUR 219 |
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Amplite™ Fluorimetric Peroxidase (HRP) Assay Kit *Near Infrared Fluorescence* |
11553 |
AAT Bioquest |
500 Tests |
EUR 306 |
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Amplite™ Luminometric Peroxidase (HRP) Assay Kit |
11559 |
AAT Bioquest |
500 Tests |
EUR 219 |
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Amplite™ Fluorimetric Glutathione Peroxidase Assay Kit *Blue Fluorescence* |
11560 |
AAT Bioquest |
200 Tests |
EUR 306 |
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FDP [Fluorescein diphosphate, tetraammonium salt] *CAS 217305-49-2* |
11600 |
AAT Bioquest |
5 mg |
EUR 132 |
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MUP, disodium salt [4-Methylumbelliferyl phosphate, disodium salt] *CAS 22919-26-2* |
11610 |
AAT Bioquest |
25 mg |
EUR 115 |
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MUP, disodium salt [4-Methylumbelliferyl phosphate, disodium salt] *CAS 22919-26-2* |
11612 |
AAT Bioquest |
10 g |
EUR 898 |
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MUP [4-Methylumbelliferyl phosphate, free acid] *CAS 3368-04-5* |
11614 |
AAT Bioquest |
25 mg |
EUR 115 |
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MUP [4-Methylumbelliferyl phosphate, free acid] *CAS 3368-04-5* |
11617 |
AAT Bioquest |
5 g |
EUR 480 |
|
pNPP [4-Nitrophenyl phosphate, disodium salt] *CAS 4264-83-9* |
11619 |
AAT Bioquest |
25 mg |
EUR 115 |
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CF-MUP, sodium salt *Superior alternative to MUP* |
11628 |
AAT Bioquest |
10 mg |
EUR 50 |
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Amplite™ Colorimetric Alkaline Phosphatase Assay Kit *Yellow Color* |
11950 |
AAT Bioquest |
500 Tests |
EUR 176 |
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Amplite™ Fluorimetric Alkaline Phosphatase Assay Kit *Blue Fluorescence* |
11952 |
AAT Bioquest |
500 Tests |
EUR 219 |
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Amplite™ Fluorimetric Alkaline Phosphatase Assay Kit *Green Fluorescence* |
11953 |
AAT Bioquest |
500 Tests |
EUR 219 |
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Amplite™ Fluorimetric Alkaline Phosphatase Assay Kit *Near Infrared Fluorescence* |
11954 |
AAT Bioquest |
500 Tests |
EUR 219 |
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Amplite™ Luminometric Alkaline Phosphatase Assay Kit *Luminescence* |
11956 |
AAT Bioquest |
100 Tests |
EUR 219 |
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ReadiLink™ Rapid iFluor™ 555 Antibody Labeling Kit *Microscale Optimized for Labeling 50 µg Antibody Per Reaction* |
1227 |
AAT Bioquest |
2 Labelings |
EUR 176 |
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ReadiLink™ Rapid iFluor™ 647 Antibody Labeling Kit *Microscale Optimized for Labeling 50 µg Antibody Per Reaction* |
1235 |
AAT Bioquest |
2 Labelings |
EUR 176 |
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ReadiLink™ Rapid iFluor™ 680 Antibody Labeling Kit *Microscale Optimized for Labeling 50 µg Antibody Per Reaction* |
1240 |
AAT Bioquest |
2 Labelings |
EUR 176 |
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ReadiLink™ Rapid iFluor™ 700 Antibody Labeling Kit *Microscale Optimized for Labeling 50 µg Antibody Per Reaction* |
1245 |
AAT Bioquest |
2 Labelings |
EUR 176 |
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Cyluc1 [(4S)-2-(6,7-Dihydro-5H-thiazolo[4,5-f]indol-2-yl)-4,5-dihydro-thiazole-4-carboxylic acid] |
12481 |
AAT Bioquest |
25 mg |
EUR 219 |
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Cyluc1 [(4S)-2-(6,7-Dihydro-5H-thiazolo[4,5-f]indol-2-yl)-4,5-dihydro-thiazole-4-carboxylic acid] |
12482 |
AAT Bioquest |
100 mg |
EUR 480 |
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ReadiLink™ Rapid iFluor™ 750 Antibody Labeling Kit *Microscale Optimized for Labeling 50 µg Antibody Per Reaction* |
1250 |
AAT Bioquest |
2 Labelings |
EUR 176 |
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D-Luciferin, free acid *CAS#: 2591-17-5* |
12501 |
AAT Bioquest |
25 mg |
EUR 115 |
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D-Luciferin, free acid *CAS#: 2591-17-5* |
12502 |
AAT Bioquest |
100 mg |
EUR 132 |
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D-Luciferin, free acid *CAS#: 2591-17-5* |
12503 |
AAT Bioquest |
1 g |
EUR 528 |
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D-Luciferin, potassium salt *CAS#: 115144-35-9* |
12505 |
AAT Bioquest |
25 mg |
EUR 115 |
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D-Luciferin, potassium salt *CAS#: 115144-35-9* |
12506 |
AAT Bioquest |
100 mg |
EUR 132 |
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D-Luciferin, potassium salt *CAS#: 115144-35-9* |
12507 |
AAT Bioquest |
1 g |
EUR 263 |
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D-Luciferin, sodium salt *CAS#: 103404-75-7* |
12509 |
AAT Bioquest |
25 mg |
EUR 115 |
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D-Luciferin, sodium salt *CAS#: 103404-75-7* |
12510 |
AAT Bioquest |
100 mg |
EUR 132 |
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D-Luciferin, sodium salt *CAS#: 103404-75-7* |
12511 |
AAT Bioquest |
1 g |
EUR 528 |
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D-Luciferin phosphate *CAS 145613-12-3* |
12512 |
AAT Bioquest |
1 mg |
EUR 219 |
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D-Luciferin galactoside *CAS 131474-38-9* |
12513 |
AAT Bioquest |
5 mg |
EUR 219 |
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D-Luciferin methyl ester *CAS 73918-26-0* |
12514 |
AAT Bioquest |
5 mg |
EUR 219 |
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D-Luciferin ethyl ester *CAS 135251-85-3* |
12515 |
AAT Bioquest |
5 mg |
EUR 219 |
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Amplite™ Luciferase Reporter Gene Assay Kit *Bright Glow* |
12518 |
AAT Bioquest |
1 plate |
EUR 176 |
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Amplite™ Luciferase Reporter Gene Assay Kit *Bright Glow* |
12519 |
AAT Bioquest |
10 plates |
EUR 393 |
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Amplite™ Luciferase Reporter Gene Assay Kit *Bright Glow* |
12520 |
AAT Bioquest |
100 plates |
EUR 2616 |
|
Amplite™ Gaussia Luciferase Reporter Gene Assay Kit *Bright Glow* |
12530 |
AAT Bioquest |
1 plate |
EUR 219 |
|
Amplite™ Gaussia Luciferase Reporter Gene Assay Kit *Bright Glow* |
12531 |
AAT Bioquest |
10 Plates |
EUR 702 |
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Amplite™ Gaussia Luciferase Reporter Gene Assay Kit *Bright Glow* |
12532 |
AAT Bioquest |
100 plates |
EUR 3486 |
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Amplite™ Renilla Luciferase Reporter Gene Assay Kit *Bright Glow* |
12535 |
AAT Bioquest |
1 plate |
EUR 219 |
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Amplite™ Renilla Luciferase Reporter Gene Assay Kit *Bright Glow* |
12536 |
AAT Bioquest |
10 plates |
EUR 876 |
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Amplite™ Renilla Luciferase Reporter Gene Assay Kit *Bright Glow* |
12537 |
AAT Bioquest |
100 plates |
EUR 3486 |
|
ReadiLink™ Rapid iFluor™ 488 Antibody Labeling Kit *Microscale Optimized for Labeling 50 µg Antibody Per Reaction* |
1255 |
AAT Bioquest |
2 Labelings |
EUR 176 |
|
Amplite™ Colorimetric Beta-Lactamase Activity Assay Kit |
12551 |
AAT Bioquest |
200 Tests |
EUR 393 |
|
BG-NH2 [O6-(4-Aminomethyl-benzyl)guanine] |
12560 |
AAT Bioquest |
1 mg |
EUR 219 |
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BG-NH2 [O6-(4-Aminomethyl-benzyl)guanine] |
12561 |
AAT Bioquest |
5 mg |
EUR 393 |
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ReadiLink™ Rapid iFluor™ 633 Antibody Labeling Kit *Microscale Optimized for Labeling 50 µg Antibody Per Reaction* |
1260 |
AAT Bioquest |
2 Labelings |
EUR 176 |
|
Amplite™ Fluorimetric Beta-Galactosidase Assay Kit *Green Fluorescence* |
12601 |
AAT Bioquest |
500 Tests |
EUR 306 |
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Amplite™ Fluorimetric Neuraminidase Assay Kit *Blue Fluorescence* |
12602 |
AAT Bioquest |
200 Tests |
EUR 306 |
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Amplite™ Fluorimetric Beta-Galactosidase Assay Kit *Red Fluorescence* |
12603 |
AAT Bioquest |
200 Tests |
EUR 306 |
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Amplite™ Colorimetric Beta-Galactosidase Assay Kit |
12604 |
AAT Bioquest |
200 Tests |
EUR 306 |
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HIS Lite™ Cy3 Bis NTA-Ni Complex |
12610 |
AAT Bioquest |
1 mg |
EUR 393 |
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HIS Lite™ Cy5 Bis NTA-Ni Complex |
12613 |
AAT Bioquest |
1 mg |
EUR 393 |
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ReadiLink™ Rapid iFluor™ 790 Antibody Labeling Kit *Microscale Optimized for Labeling 50 µg Antibody Per Reaction* |
1265 |
AAT Bioquest |
2 Labelings |
EUR 176 |
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ReadiLink™ Rapid Cy3 Antibody Labeling Kit *Microscale Optimized for Labeling 50 µg Antibody Per Reaction* |
1290 |
AAT Bioquest |
2 Labelings |
EUR 176 |
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ReadiLink™ Rapid Cy5 Antibody Labeling Kit *Microscale Optimized for Labeling 50 µg Antibody Per Reaction* |
1292 |
AAT Bioquest |
2 Labelings |
EUR 176 |
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ReadiLink™ Rapid Cy7 Antibody Labeling Kit *Microscale Optimized for Labeling 50 µg Antibody Per Reaction* |
1294 |
AAT Bioquest |
2 Labelings |
EUR 176 |
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ReadiLink™ Rapid FITC Antibody Labeling Kit *Microscale Optimized for Labeling 50 µg Antibody Per Reaction* |
1299 |
AAT Bioquest |
2 Labelings |
EUR 176 |
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ReadiLink™ Rapid trFluor™ Eu Antibody Labeling Kit *Microscale Optimized for Labeling 50 ug Antibody Per Reaction* |
1300 |
AAT Bioquest |
2 Labelings |
EUR 876 |
|
Benzoyl-Leu-Gly-Arg-Aminoluciferin |
13000 |
AAT Bioquest |
1 mg |
EUR 480 |
|
BOC-Leu-Gly-Arg-Aminoluciferin |
13001 |
AAT Bioquest |
1 mg |
EUR 480 |
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BOC-Val-Pro-Arg-Aminoluciferin |
13002 |
AAT Bioquest |
1 mg |
EUR 480 |
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D-VLK-AMC [D-Val-Leu-Lys-AMC] |
13201 |
AAT Bioquest |
5 mg |
EUR 132 |
|
Ac-DEVD-AFC *CAS 201608-14-2* |
13401 |
AAT Bioquest |
5 mg |
EUR 132 |
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Ac-DEVD-AMC *CAS 169332-61-0* |
13402 |
AAT Bioquest |
5 mg |
EUR 132 |
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Ac-DEVD-CHO *CAS 169332-60-9* |
13403 |
AAT Bioquest |
1 mg |
EUR 132 |
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Ac-DEVD-pNA *CAS 189950-66-1* |
13405 |
AAT Bioquest |
5 mg |
EUR 132 |
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Ac-IETD-AFC *CAS 211990-57-7* |
13410 |
AAT Bioquest |
5 mg |
EUR 219 |
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Ac-IETD-CHO *CAS 191338-86-0* |
13412 |
AAT Bioquest |
5 mg |
EUR 219 |
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Z-IETD-pNA *CAS 219138-21-3* |
13413 |
AAT Bioquest |
5 mg |
EUR 219 |
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Buccutite™ Rapid PE-Cy7 Tandem Antibody Labeling Kit *Microscale Optimized for Labeling 25 ug Antibody Per Reaction* |
1342 |
AAT Bioquest |
2 Labelings |
EUR 306 |
|
Z-IETD-AFC *CAS 219138-02-0* |
13425 |
AAT Bioquest |
5 mg |
EUR 158 |
|
Ac-LEHD-AMC *CAS 292633-16-0* |
13426 |
AAT Bioquest |
5 mg |
EUR 176 |
|
Leu-AMC [L-Leucine-7-amido-4-methylcoumarin] *CAS 62480-44-8* |
13445 |
AAT Bioquest |
10 mg |
EUR 176 |
|
Gly-Pro-AMC *CAS 115035-46-6* |
13450 |
AAT Bioquest |
5 mg |
EUR 132 |
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Amplite™ Fluorimetric Proteasome 20S Activity Assay Kit *Green Fluorescence* |
13456 |
AAT Bioquest |
100 tests |
EUR 306 |
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Issues in human resources, regulatory environment and sustainability have been challenging the network from continuing growth. Clinical researchers have full-time clinical responsibilities in China and it is thus important to build a cadre of other human resources to assist. The regulatory environment is becoming friendlier in China to introduce international clinical trials to the CTCTC network.The CTCTC, with mature management structure and sustainable development model, which are distilled five key lessons for other developing countries or investigators of interest. They are the respectively using assessment-based approach to design tailored training package, understanding the availability of clinical researchers, providing solutions to maintain sustainability, understanding local regulatory environments and working with an international organization with local on-site team, respectively. Although, the experiences and capacity of China’s TB hospitals in conducting clinical research vary. Considerable efforts to continue building the capacity are still needed, although the gap is smaller for a few top-tier hospitals.