The China tuberculosis clinical trials consortium network: a model for international TB clinical trials capacity building.

With the second largest tuberculosis (TB) burden globally, China is committed to actively engage in international TB clinical trials to contribute to global TB research. However, lack of research capacity among local sites has been identified as a barrier.

The China Tuberculosis Clinical Trials Consortium (CTCTC) was initiated by Beijing Chest Hospital with investment from the US National Institutes of Health and technical support from Family Health International 360 in 2013, as a nationwide collaborative clinical trial network to strengthen selected clinical site research capacity and attract TB clinical trials.

The program aims to: 1) recruit leading hospitals that care for TB patients; 2) conduct on-site assessment to identify capacity gaps and needs for improvement; 3) design and deliver capacity building activities; 4) attract and deliver high quality results for TB clinical trials.

A total of 24 sites have joined CTCTC, covering 20 provinces in China. Twenty-two sites have been accredited by the National Medical Products Administration (NMPA) to be qualified to conduct TB clinical trials. The onsite assessment, extensive trainings among the CTCTC sites and young investigators have resulted in better understanding and improvement of the site capacity in conducting TB clinical trials.

The establishment and growth of the CTCTC network has benefited from the good leadership, effective international cooperation and local commitment.

Amplite™ Colorimetric Malondialdehyde (MDA) Quantitation Kit
10070 200 Tests
EUR 350

Amplite™ Fluorimetric Malondialdehyde (MDA) Quantitation Kit
10071 200 Tests
EUR 350

Amplite™ Colorimetric α-Ketoglutarate Quantitation Kit
10085 200 Tests
EUR 393

Amplite™ Fluorimetric α-Ketoglutarate Quantitation Kit
10087 200 Tests
EUR 393

iFluor™ 610 succinimidyl ester
1038 1 mg
EUR 219

iFluor™ A7 SE
1039 1 mg
EUR 219

iFluor™ 546 succinimidyl ester
1048 1 mg
EUR 219

iFluor™ 568 succinimidyl ester
1049 1 mg
EUR 219

iFluor™ 450 maleimide
1057 1 mg
EUR 219

iFluor™ 647 amine
1074 1 mg
EUR 219

iFluor™ 680 amine
1076 1 mg
EUR 219

iFluor™ 700 amine
1077 1 mg
EUR 219

iFluor™ 710 amine
1078 1 mg
EUR 219

iFluor™ 750 amine
1079 1 mg
EUR 219

iFluor™ 680 hydrazide
1086 1 mg
EUR 219

iFluor™ 700 hydrazide
1087 1 mg
EUR 219

iFluor™ 750 hydrazide
1088 1 mg
EUR 219

ReadiUse™ ABTS Substrate Solution *Optimized for ELISA Assays with HRP Conjugates*
11001 1 L
EUR 202

ReadiUse™ TMB Substrate Solution *Optimized for ELISA Assays with HRP Conjugates*
11003 1 L
EUR 480

ReadiUse™ hydrogen peroxide solution *50 mM calibrated and stabilized solution*
11004 5x10 mL
EUR 132

Amplite™ Blue
11005 25 mg
EUR 176

Amplite™ IR
11009 1 mg
EUR 132

Amplite™ Red
11011 1000 Assays
EUR 132

ReadiUse™ TMB Substrate Solution *Optimized for ELISA Assays with HRP Conjugates*
11012 100 ml
EUR 115

ReadiLink™ Rapid mFluor™ Violet 420 Antibody Labeling Kit *Microscale Optimized for Labeling 50 µg Antibody Per Reaction*
1105 2 Labelings
EUR 176

Luminol [3-Aminophthalhydrazide] *CAS 521-31-3*
11050 1 g
EUR 115

iFluor™ 488 tyramide
11060 1 mg
EUR 219

Azido-Cy5 tyramide
11061 1 mg
EUR 306

Amplite™ Fluorimetric Fluorescamine Protein Quantitation Kit *Blue Fluorescence*
11100 200 Tests
EUR 219

Amplite™ Fluorimetric Protein Quantitation Kit *Orange Fluorescence*
11105 500 tests
EUR 219

ReadiLink™ Rapid mFluor™ Violet 540 Antibody Labeling Kit *Microscale Optimized for Labeling 50 µg Antibody Per Reaction*
1114 2 Labelings
EUR 176

ReadiLink™ Rapid mFluor™ Blue 570 Antibody Labeling Kit *Microscale Optimized for Labeling 50 µg Antibody Per Reaction*
1120 2 Labelings
EUR 176

ReadiLink™ Rapid mFluor™ Green 620 Antibody Labeling Kit *Microscale Optimized for Labeling 50 µg Antibody Per Reaction*
1123 2 Labelings
EUR 176

ReadiLink™ Rapid mFluor™ Yellow 630 Antibody Labeling Kit *Microscale Optimized for Labeling 50 µg Antibody Per Reaction*
1126 2 Labelings
EUR 50

Amplite™ Colorimetric Glucose Oxidase Assay Kit
11299 500 Tests
EUR 306

ReadiLink™ Rapid mFluor™ Red 700 Antibody Labeling Kit *Microscale Optimized for Labeling 50 µg Antibody Per Reaction*
1130 2 Labelings
EUR 176

Amplite™ Fluorimetric Glucose Oxidase Assay Kit *Red Fluorescence*
11300 500 Tests
EUR 219

Amplite™ Fluorimetric Myeloperoxidase Assay Kit *Red Fluorescence*
11301 200 Tests
EUR 219

Amplite™ Fluorimetric Glutamate Oxidase Assay Kit *Red Fluorescence*
11302 200 Tests
EUR 219

Amplite™ Fluorimetric Monoamine Oxidase Assay Kit *Red Fluorescence*
11303 200 Tests
EUR 219

Amplite™ Fluorimetric Xanthine Oxidase Assay Kit *Red Fluorescence*
11304 200 Tests
EUR 219

Amplite™ Colorimetric Superoxide Dismutase (SOD) Assay Kit
11305 200 Tests
EUR 219

Amplite™ Fluorimetric Catalase Assay Kit *Red Fluorescence*
11306 200 Tests
EUR 219

Amplite™ Colorimetric Xanthine Oxidase Assay Kit
11307 200 Tests
EUR 219

mFluor™ Violet 450 acid
1140 5 mg
EUR 219

Amplite™ Colorimetric Acetylcholinesterase Assay Kit
11400 200 Tests
EUR 219

Amplite™ Fluorimetric Acetylcholinesterase Assay Kit *Green Fluorescence*
11401 200 Tests
EUR 219

Amplite™ Fluorimetric Acetylcholinesterase Assay Kit *Red Fluorescence*
11402 200 Tests
EUR 219

Amplite™ Fluorimetric Acetylcholine Assay Kit *Red Fluorescence*
11403 200 Tests
EUR 219

mFluor™ Violet 510 acid
1141 5 mg
EUR 306

mFluor™ Violet 540 acid
1142 5 mg
EUR 306

mFluor™ Blue 570 acid
1143 5 mg
EUR 306

mFluor™ Green 620 acid
1144 5 mg
EUR 306

mFluor™ Yellow 630 acid
1145 5 mg
EUR 50

mFluor™ Red 700 acid
1146 5 mg
EUR 306

mFluor™ Violet 500 SE
1149 1 mg
EUR 219

mFluor™ Violet 450 SE
1150 1 mg
EUR 219

Cell Meter™ Intracellular Fluorimetric Hydrogen Peroxide Assay Kit *Green Fluorescence*
11503 200 Tests
EUR 263

Cell Meter™ Intracellular Fluorimetric Hydrogen Peroxide Assay Kit *Blue Fluorescence*
11504 100 Tests
EUR 263

Cell Meter™ Intracellular Fluorimetric Hydrogen Peroxide Assay Kit *Blue Fluorescence Optimized for Flow Cytometry*
11505 100 Tests
EUR 263

Cell Meter™ Intracellular Fluorimetric Hydrogen Peroxide Assay Kit *Green Fluorescence Optimized for Flow Cytometry*
11506 100 Tests
EUR 263

mFluor™ Violet 510 SE
1151 1 mg
EUR 219

mFluor™ Violet 540 SE
1152 1 mg
EUR 219

Amplite™ Fluorimetric Goat Anti-Mouse IgG-HRP Conjugate ELISA Assay Kit *Red Fluorescence*
11540 1000 Tests
EUR 219

Amplite™ Fluorimetric Goat Anti-Rabbit IgG-HRP Conjugate ELISA Assay Kit *Red Fluorescence*
11541 1000 Tests
EUR 219

Amplite™ Colorimetric Peroxidase (HRP) Assay Kit *Blue Color*
11551 500 Tests
EUR 219

Amplite™ Fluorimetric Peroxidase (HRP) Assay Kit *Red Fluorescence*
11552 500 Tests
EUR 219

Amplite™ Fluorimetric Peroxidase (HRP) Assay Kit *Near Infrared Fluorescence*
11553 500 Tests
EUR 306

Amplite™ Luminometric Peroxidase (HRP) Assay Kit
11559 500 Tests
EUR 219

Amplite™ Fluorimetric Glutathione Peroxidase Assay Kit *Blue Fluorescence*
11560 200 Tests
EUR 306

mFluor™ Blue 570 SE
1160 1 mg
EUR 306

FDP [Fluorescein diphosphate, tetraammonium salt] *CAS 217305-49-2*
11600 5 mg
EUR 132

MUP, disodium salt [4-Methylumbelliferyl phosphate, disodium salt] *CAS 22919-26-2*
11610 25 mg
EUR 115

MUP, disodium salt [4-Methylumbelliferyl phosphate, disodium salt] *CAS 22919-26-2*
11612 10 g
EUR 898

MUP [4-Methylumbelliferyl phosphate, free acid] *CAS 3368-04-5*
11614 25 mg
EUR 115

MUP [4-Methylumbelliferyl phosphate, free acid] *CAS 3368-04-5*
11617 5 g
EUR 480

pNPP [4-Nitrophenyl phosphate, disodium salt] *CAS 4264-83-9*
11619 25 mg
EUR 115

CF-MUP, sodium salt *Superior alternative to MUP*
11628 10 mg
EUR 50

mFluor™ Green 620 SE
1165 1 mg
EUR 306

mFluor™ Yellow 630 SE
1170 1 mg
EUR 50

ADP-ribose-pNP
11700 1 mg
EUR 219

mFluor™ Red 780 SE
1191 1 mg
EUR 306

Amplite™ Colorimetric Alkaline Phosphatase Assay Kit *Yellow Color*
11950 500 Tests
EUR 176

Amplite™ Fluorimetric Alkaline Phosphatase Assay Kit *Blue Fluorescence*
11952 500 Tests
EUR 219

Amplite™ Fluorimetric Alkaline Phosphatase Assay Kit *Green Fluorescence*
11953 500 Tests
EUR 219

Amplite™ Fluorimetric Alkaline Phosphatase Assay Kit *Near Infrared Fluorescence*
11954 500 Tests
EUR 219

Amplite™ Luminometric Alkaline Phosphatase Assay Kit *Luminescence*
11956 100 Tests
EUR 219

ReadiLink™ Rapid iFluor™ 555 Antibody Labeling Kit *Microscale Optimized for Labeling 50 µg Antibody Per Reaction*
1227 2 Labelings
EUR 176

ReadiLink™ Rapid iFluor™ 647 Antibody Labeling Kit *Microscale Optimized for Labeling 50 µg Antibody Per Reaction*
1235 2 Labelings
EUR 176

ReadiLink™ Rapid iFluor™ 680 Antibody Labeling Kit *Microscale Optimized for Labeling 50 µg Antibody Per Reaction*
1240 2 Labelings
EUR 176

ReadiLink™ Rapid iFluor™ 700 Antibody Labeling Kit *Microscale Optimized for Labeling 50 µg Antibody Per Reaction*
1245 2 Labelings
EUR 176

Cyluc1 [(4S)-2-(6,7-Dihydro-5H-thiazolo[4,5-f]indol-2-yl)-4,5-dihydro-thiazole-4-carboxylic acid]
12481 25 mg
EUR 219

Cyluc1 [(4S)-2-(6,7-Dihydro-5H-thiazolo[4,5-f]indol-2-yl)-4,5-dihydro-thiazole-4-carboxylic acid]
12482 100 mg
EUR 480

ReadiLink™ Rapid iFluor™ 750 Antibody Labeling Kit *Microscale Optimized for Labeling 50 µg Antibody Per Reaction*
1250 2 Labelings
EUR 176

D-Luciferin, free acid *CAS#: 2591-17-5*
12501 25 mg
EUR 115

D-Luciferin, free acid *CAS#: 2591-17-5*
12502 100 mg
EUR 132

D-Luciferin, free acid *CAS#: 2591-17-5*
12503 1 g
EUR 528

D-Luciferin, potassium salt *CAS#: 115144-35-9*
12505 25 mg
EUR 115

D-Luciferin, potassium salt *CAS#: 115144-35-9*
12506 100 mg
EUR 132

D-Luciferin, potassium salt *CAS#: 115144-35-9*
12507 1 g
EUR 263

D-Luciferin, sodium salt *CAS#: 103404-75-7*
12509 25 mg
EUR 115

D-Luciferin, sodium salt *CAS#: 103404-75-7*
12510 100 mg
EUR 132

D-Luciferin, sodium salt *CAS#: 103404-75-7*
12511 1 g
EUR 528

D-Luciferin phosphate *CAS 145613-12-3*
12512 1 mg
EUR 219

D-Luciferin galactoside *CAS 131474-38-9*
12513 5 mg
EUR 219

D-Luciferin methyl ester *CAS 73918-26-0*
12514 5 mg
EUR 219

D-Luciferin ethyl ester *CAS 135251-85-3*
12515 5 mg
EUR 219

D-Luciferin acetate
12516 5 mg
EUR 219

Amplite™ Luciferase Reporter Gene Assay Kit *Bright Glow*
12518 1 plate
EUR 176

Amplite™ Luciferase Reporter Gene Assay Kit *Bright Glow*
12519 10 plates
EUR 393

Amplite™ Luciferase Reporter Gene Assay Kit *Bright Glow*
12520 100 plates
EUR 2616

Amplite™ Gaussia Luciferase Reporter Gene Assay Kit *Bright Glow*
12530 1 plate
EUR 219

Amplite™ Gaussia Luciferase Reporter Gene Assay Kit *Bright Glow*
12531 10 Plates
EUR 702

Amplite™ Gaussia Luciferase Reporter Gene Assay Kit *Bright Glow*
12532 100 plates
EUR 3486

Amplite™ Renilla Luciferase Reporter Gene Assay Kit *Bright Glow*
12535 1 plate
EUR 219

Amplite™ Renilla Luciferase Reporter Gene Assay Kit *Bright Glow*
12536 10 plates
EUR 876

Amplite™ Renilla Luciferase Reporter Gene Assay Kit *Bright Glow*
12537 100 plates
EUR 3486

ReadiLink™ Rapid iFluor™ 488 Antibody Labeling Kit *Microscale Optimized for Labeling 50 µg Antibody Per Reaction*
1255 2 Labelings
EUR 176

Amplite™ Colorimetric Beta-Lactamase Activity Assay Kit
12551 200 Tests
EUR 393

BG-NH2 [O6-(4-Aminomethyl-benzyl)guanine]
12560 1 mg
EUR 219

BG-NH2 [O6-(4-Aminomethyl-benzyl)guanine]
12561 5 mg
EUR 393

ReadiLink™ Rapid iFluor™ 633 Antibody Labeling Kit *Microscale Optimized for Labeling 50 µg Antibody Per Reaction*
1260 2 Labelings
EUR 176

Amplite™ Fluorimetric Beta-Galactosidase Assay Kit *Green Fluorescence*
12601 500 Tests
EUR 306

Amplite™ Fluorimetric Neuraminidase Assay Kit *Blue Fluorescence*
12602 200 Tests
EUR 306

Amplite™ Fluorimetric Beta-Galactosidase Assay Kit *Red Fluorescence*
12603 200 Tests
EUR 306

Amplite™ Colorimetric Beta-Galactosidase Assay Kit
12604 200 Tests
EUR 306

HIS Lite™ Cy3 Bis NTA-Ni Complex
12610 1 mg
EUR 393

HIS Lite™ Cy5 Bis NTA-Ni Complex
12613 1 mg
EUR 393

ReadiLink™ Rapid iFluor™ 790 Antibody Labeling Kit *Microscale Optimized for Labeling 50 µg Antibody Per Reaction*
1265 2 Labelings
EUR 176

ReadiLink™ Rapid Cy3 Antibody Labeling Kit *Microscale Optimized for Labeling 50 µg Antibody Per Reaction*
1290 2 Labelings
EUR 176

ReadiLink™ Rapid Cy5 Antibody Labeling Kit *Microscale Optimized for Labeling 50 µg Antibody Per Reaction*
1292 2 Labelings
EUR 176

ReadiLink™ Rapid Cy7 Antibody Labeling Kit *Microscale Optimized for Labeling 50 µg Antibody Per Reaction*
1294 2 Labelings
EUR 176

ReadiLink™ Rapid FITC Antibody Labeling Kit *Microscale Optimized for Labeling 50 µg Antibody Per Reaction*
1299 2 Labelings
EUR 176

ReadiLink™ Rapid trFluor™ Eu Antibody Labeling Kit *Microscale Optimized for Labeling 50 ug Antibody Per Reaction*
1300 2 Labelings
EUR 876

Benzoyl-Leu-Gly-Arg-Aminoluciferin
13000 1 mg
EUR 480

BOC-Leu-Gly-Arg-Aminoluciferin
13001 1 mg
EUR 480

BOC-Val-Pro-Arg-Aminoluciferin
13002 1 mg
EUR 480

D-VLK-AMC [D-Val-Leu-Lys-AMC]
13201 5 mg
EUR 132

Ac-DEVD-AFC *CAS 201608-14-2*
13401 5 mg
EUR 132

Ac-DEVD-AMC *CAS 169332-61-0*
13402 5 mg
EUR 132

Ac-DEVD-CHO *CAS 169332-60-9*
13403 1 mg
EUR 132

Ac-DEVD-pNA *CAS 189950-66-1*
13405 5 mg
EUR 132

Ac-IETD-AFC *CAS 211990-57-7*
13410 5 mg
EUR 219

Ac-IETD-AMC
13411 5 mg
EUR 219

Ac-IETD-CHO *CAS 191338-86-0*
13412 5 mg
EUR 219

Z-IETD-pNA *CAS 219138-21-3*
13413 5 mg
EUR 219

D-Aminoluciferin
13415 10 mg
EUR 219

Buccutite™ Rapid PE-Cy7 Tandem Antibody Labeling Kit *Microscale Optimized for Labeling 25 ug Antibody Per Reaction*
1342 2 Labelings
EUR 306

Z-DEVD-AMC
13421 5 mg
EUR 176

Z-IETD-AFC *CAS 219138-02-0*
13425 5 mg
EUR 158

Ac-LEHD-AMC *CAS 292633-16-0*
13426 5 mg
EUR 176

(Ac-LEHD)2-R110
13427 1 mg
EUR 132

(Ac-IETD)2-R110
13431 1 mg
EUR 132

Z-DEVD-ProRed™ 620
13433 1 mg
EUR 306

Z-IETD-ProRed™ 620
13434 1 mg
EUR 306

Z-LEHD-ProRed™ 620
13435 1 mg
EUR 306

Leu-AMC [L-Leucine-7-amido-4-methylcoumarin] *CAS 62480-44-8*
13445 10 mg
EUR 176

Gly-Pro-AMC *CAS 115035-46-6*
13450 5 mg
EUR 132

(Suc-LLVY)2R110
13451 1 mg
EUR 132

Suc-LLVY-Aminoluciferin
13452 1 mg
EUR 219

Suc-LLVY-AMC
13453 1 mg
EUR 132

(Ac-ANW)2R110
13455 1 mg
EUR 219

Amplite™ Fluorimetric Proteasome 20S Activity Assay Kit *Green Fluorescence*
13456 100 tests
EUR 306

Pro-AMC
13457 5 mg
EUR 132

Ala-AMC
13458 5 mg
EUR 132

D-Ala-AMC *CAS 201847-52-1*
13459 5 mg
EUR 132

MeO-Succ-Arg-Pro-Tyr-AMC
13460 5 mg
EUR 132

BOC-Val-Pro-Arg-AMC
13461 5 mg
EUR 132

(BOC-VPR)2R110
13462 1 mg
EUR 132

(Ac-KQL)2R110
13465 1 mg
EUR 132

Issues in human resources, regulatory environment and sustainability have been challenging the network from continuing growth. Clinical researchers have full-time clinical responsibilities in China and it is thus important to build a cadre of other human resources to assist. The regulatory environment is becoming friendlier in China to introduce international clinical trials to the CTCTC network.The CTCTC, with mature management structure and sustainable development model, which are distilled five key lessons for other developing countries or investigators of interest. They are the respectively using assessment-based approach to design tailored training package, understanding the availability of clinical researchers, providing solutions to maintain sustainability, understanding local regulatory environments and working with an international organization with local on-site team, respectively. Although, the experiences and capacity of China’s TB hospitals in conducting clinical research vary. Considerable efforts to continue building the capacity are still needed, although the gap is smaller for a few top-tier hospitals.